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For practitioners
A daily saffron drink, with the research laid out plainly.
Mood Mod is a sugar-free drink mix built on Affron™, a standardized saffron extract studied in human mood trials. Here is what is in it, what the research shows and what it doesn't, and how to recommend it to the people you work with.
What is in one stick
30mg
Affron™ saffron extract
200mg
L-theanine
100mg
Magnesium glycinate
B6 + B12
B vitamins
The research on Affron™
Four randomized, double-blind, placebo-controlled trials used Affron™ at 28mg a day, including one in teens. We show the placebo result next to every number, because it matters.
72% vs 54%reached a clinically meaningful improvement on the primary mood measure (DASS-21), Affron vs placebo, p = 0.010
202 adults aged 18 to 70 with low mood, 12 weeks
Described by its authors as the largest saffron trial to date. The primary outcome improved more with Affron than placebo (Cohen's d = 0.39). Other secondary outcomes showed no difference between groups, and the authors note a large placebo response.
Lopresti et al., Journal of Nutrition, 2025. PMID 4041430149% vs 26%reached a clinically meaningful improvement on the primary mood measure (DASS-21), Affron vs placebo, p = 0.026
86 women aged 50 to 70 with low mood and poor sleep, 12 weeks
Self-esteem and sleep-related impairment also improved, which the authors call exploratory. Sleep disturbance itself showed no difference between groups (p = 0.786).
Lopresti and Smith, Frontiers in Nutrition, 2026. PMID 4238970828mg vs 22mg28mg improved overall mood scores vs placebo (POMS, p < 0.001). 22mg showed no effect.
128 adults with self-reported low mood, not diagnosed, 4 weeks
The earliest Affron mood trial, and the reason dose matters: the lower dose did nothing. Its main limitation is that screening and outcomes were self-reported.
Kell et al., Complementary Therapies in Medicine, 2017. PMID 2873582633% vs 17%average drop in youth-reported anxiety and low-mood scores (RCADS), Affron vs placebo, p = 0.029
80 teens aged 12 to 16 with mild to moderate anxiety or low mood, 8 weeks
Affron at 14mg twice a day (28mg total). The teens' own reports improved more with Affron than placebo, and it was well tolerated. Parent reports were less consistent, which the authors flag as a limitation.
Lopresti et al., Journal of Affective Disorders, 2018. PMID 29510352Two things we would rather you hear from us.
- All four trials were funded by or involved Pharmactive, the company that makes Affron™.
- None of this shows that Mood Mod treats, cures or prevents any condition. The trials studied the extract, not our drink. L-theanine and magnesium glycinate are included at commonly used amounts, and we make no claims for them here.
Safety and fit
Serotonergic
Saffron has serotonergic activity. We don't suggest Mood Mod alongside SSRIs, SNRIs or other serotonergic medication or supplements without a clinician's okay.
Pregnancy
Not for use during pregnancy or while breastfeeding.
Your judgment leads
For anyone on prescription medication or managing a diagnosed condition, clinician judgment comes first. Designed for ages 13 and up; for anyone under 18, a parent and clinician should be part of the decision.
Working with your practice
A free bag for you
A 20-day bag to try yourself, no strings attached.
A code for your patients
A personal code that gives the people you work with a discount.
Commission
A commission on what your patients order with your code. Dispense in-clinic? Ask us about practice pricing.
30-day guarantee
Every order is covered by our 30-day money-back guarantee, opened or unopened.
Request a free sample
Tell us where to send it. Jay, our founder, follows up personally.
Thank you. Your request is in, and your sample ships this week. Jay will be in touch.
Something went wrong sending that. Please email jay@moodmod.co and we'll take care of it.
Questions practitioners ask
How soon would someone notice anything?
The trials measured results at 4 and 12 weeks, so we suggest daily use for at least a month before judging.
Can it be combined with other supplements?
Most of the time, with your judgment. We would avoid stacking it with other serotonergic supplements such as St. John's wort or 5-HTP.
Why 30mg and not 28mg?
The trials used 28mg. Our 30mg sits in that range, and we never describe it as "the exact dose".
Who are we?
Mood Mod is a small Los Angeles company. Questions go straight to Jay, the founder, at jay@moodmod.co.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
